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These agents are indicated for patients with moderate to severe UC who have not had an adequate response or are intolerant to immunomodulator therapy

The NLRP3 inflammasome is activated by lipid peroxidation byproducts such as 4-HNE and MDA produced during ferroptosis, triggering caspase-1-dependent maturation of IL-1/IL-18, which amplifies inflammation and establishes a vicious cycle (127, 131)

Vitamin C can donate an electron to the oxidized glutathione, turning it back into its "reduced" (active) state

Baron, R., Binder, A

Some supplements require multiple doses in a day, while others are taken once daily, making them easier to stick with long-term